Generics of Remdesivir or Immune Boosters? Which is Better For The Pandemic

    First case of coronavirus was first detected in December 2019 in Wuhan, a city in China. And now today it has become a pandemic. The whole world is suffering from coronavirus outbreak. lacks of people all over the world are getting infected. Scientists and researchers all over the world are searching for vaccine and anti doses.

However some pharmaceutical companies has been successfully brought up some medications.

1. The very first medicine launched in the market for coronavirus was the drug called arsenic album 30.

This drug work for immunity by boosting it up and providing support to immune system and avoid infection. The drug consists of arsenic and zinc powder which is harmful and poisonous for animals as well as plants. Many studies claims that this medicine cannot help for curing the disease. However there is no such evidence.

2. Following the homeopathy, allopath came up with a medication called Remdesivir. Since drug act as fake RNA polymerase which is necessary for viral replication the virus can be destroyed.

The drug was first used against ebola virus which projectors  itself as fake RNA polymerases for RNA viruses like ebola and stop the internal multiplication of virus.
Coronavirus is RNA dependent virus and hence this drug may cure the patients. Ramdesivir has approved in Japan since 2014 for ebola and influenza. The same drug, in Japan is in clinical trial to prove its efficacy against covid-19.

Drugs in phase 3 trial in Japan and phase 2 trial in US. The drug is been patented by Japan but is allowed for making the generic drugs due to the medical need.

Glenmark pharmaceuticals, Cipla pharmaceutical company, mylan, Zydus cadila and DRL are licensed  from Gilead for making generic drug.

Glenmark pharmaceuticals is first Indian pharmaceutical to get approval for phase 3 clinical trial by DCGI. The generic name given by Glenmark is fabi flu.

Patients with diabetes and heart disease with mild to moderate covid-19 symptoms are eligible in this trial. The study shows the production in viral load within 4 days and provides faster radiological and symptomatic improvement in the patients. The drug shows 88% clinical improvement in covid-19 patients.

3. Cipla pharmaceutical is the only company who have approval for the production of generic drugs from us FDA as well as DCGI. 

Asian News International (ANI) reported that drug has granted permission to be used for restricted emergency use. On the other side Cipla pharmaceuticals have also produced a generic drug of Remdesivir. 

Cipremi is approved for adult and paediatric patients particularly those who are on oxygen support. Cipremi, that is Remdesivir is used as lyphilised powder for injection of 100 mg. Cipla has not yet disclosed its pricing for the medication.

DCGI has granted approval for supply drug  to cipla for Restricted Emergency Uses a part of accelerated approval process is considering the utmost medical need. Cipla pharmaceuticals will provide required training on the use of drug, informed patient consent documents post marketing surveillance as well as conduct of phase 4 clinical trial on Indian patients.

Mortality rate in the clinical trial conducted by Cipla was 7.1% among give in Remdesivir and 11.9% in Placebo. Gilead sciences had extended voluntary non-exclusive licence Cipla and hydro manufacturer  to market generic version.

4. Whereas Hetero Pharma, and other pharmaceutical company has received approval for the from the drug regulator to manufacture the generic. 

Hetero Pharma launch generic version under the name of covifor and will be selling 100mg injectables. Each vial may costing 5000 to 6000 per vial.As per ministry of dozing recommendation patients are to be given 200mg injectables of Remdesivir on day 1 followed by 100 mg daily for 5 days.

    ICMR has approved Remdesivir under Emergency Use Authorization (EUA) for use. Moreover these generic drugs may prove its efficacy. The drug, Remdesivir is included in ministry of health revised "clinical management protocols for covid-19" asa an "investigational therapy".

5. But a new therapy was put forth by Patanjali ayurved limited. It is named as corona kit the company is promoted by yoga guru Ramdev. But several doctors claims that it's just boosts up immunity and it can't be called as a drug against covid-19.

The Corona kit from Patanjali consists of  swasri(breathing difficulty), Anu Tel( used for nasal treatment) and coronil  (mixture of giloy, tulsi and ashwagandha). Patanjali Ayurveda claims that the medicine can cure covid-19 in 7 days. But the doctors adds that medicine do not do anything with the virus just boost up immunity. But government has not given any approval to the medication for marketing.

So from the above discussion we can conclude or assume that we have found out the cure for the pandemic, and Just immunity boosters will not help. Remdesivir is a Ray of hope against the pandemic. All pharmaceuticals are trying their best to find out the solution in form of medicine and vaccines. Let me know in the comment section what you feel, which is a best medicine for covid-19.